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Structure and function of the AAA + ATPase p97/Cdc48p
Abstractp97 (also known as valosin-containing protein (VCP) in mammals or Cdc48p in Saccharomyces cerevisiae) is an evolutionarily con
AAA proteases in mitochondria: diverse functions of membrane-bound proteolytic machines
FtsH/AAA proteases comprise a distinct family of membrane-bound, ATP-dependent proteases present in eubacteria and eukaryotic cells, w
m-AAA proteases, mitochondrial calcium homeostasis and neurodegeneration.
The function of mitochondria depends on ubiquitously expressed and evolutionary conserved m-AAA proteases in the inner membrane. These
Stairway to translocation: AAA+ motor structures reveal the mechanisms of ATP-dependent substrat
Translocases of the AAA+ (ATPases Associated with various cellular Activities) family are powerful molecular machines that use the mec
Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeos
p97 is a AAA-ATPase with multiple cellular functions, one of which is critical regulation of protein homeostasis pathways. We describe
The AAA+ superfamily of functionally diverse proteins.
SUMMARY The AAA+ superfamily is a large and functionally diverse superfamily of NTPases that are characterized by a conserved nucleot
Advanced, Analytic, Automated (AAA) Measurement of Engagement During Learning.
It is generally acknowledged that engagement plays a critical role in learning. Unfortunately, the study of engagement has been stymie
Protein quality control in organelles — AAA/FtsH story
AbstractThis review focuses on organellar AAA/FtsH proteases, whose proteolytic and chaperone-like activity is a crucial component of
Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.
Bacterial ClpB and yeast Hsp104 are homologous Hsp100 protein disaggregases that serve critical functions in proteostasis by solubiliz
Loss of m-AAA Protease in Mitochondria Causes Complex I Deficiency and Increased Sensitivity to
Mutations in paraplegin, a putative mitochondrial metallopeptidase of the AAA family, cause an autosomal recessive form of hereditary
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